Hammett analysis of the inhibition of pancreatic cholesterol esterase by substituted phenyl-N-butylcarbamate
1995
Abstract Substituted phenyl-N-butylcarbamates ( 1 ) as active site-directed irreversible inhibitors of pancreatic cholesterol esterase are investigated for values of the dissociation constant (K I ), the carbamylation constant (k 2 ), and the bimolecular rate constant (k i ). Linear free energy relationships between-logK I , logk 2 , or logk i and substituent constant (σ) are observed.
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