2-Substituted-1-naphthols as potent 5-lipoxygenase inhibitors with topical antiinflammatory activity
1990
The synthesis, biological evaluation, and structure-activity relationships of a series of 1-naphthols bearing carbon substituents at the 2-position are dscribed. These compounds are potent inhibitors of the 5-lipoxygenase from RBL-1 cells and also inhibit bovine seminal vesicle cyclooxygenase
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