Serum vitamin B12 associated with vitamin D/25(OH)D in women with recurrent aphthous stomatitis.

espanolAntecedentes: la deficiencia de vitamina B12 y vitamina D puede contribuir a la estomatitis aftosa recurrente (EAR). Los estudios actuales han demostrado que la vitamina B12 esta asociada con la vitamina D en mujeres, sin embargo, ningun estudio ha evaluado la vitamina B12 asociada con la vitamina D/25 (OH) D en mujeres con EAR. Objetivo: investigar la asociacion entre la vitamina B12 y la vitamina D / 25 (OH) D serica en mujeres con RAS. Material y Metodos: Cuarenta y una mujeres con RAS que cumplen con los criterios de inclusion participaron en este estudio. Los criterios de inclusion fueron mujeres con RAS y sin otras enfermedades orales. Los criterios de exclusion fueron aquellos que tenian enfermedades sistemicas, tomaban medicamentos o fumaban. Todos los sujetos se sometieron a una venupuntura para extraer sangre para cuantificar la vitamina B12 y la vitamina D/25 (OH) D en suero. Las caracteristicas de los sujetos, la severidad del EAR, la concentracion de vitamina B12 y la vitamina D/25 (OH) D serica fueron recolectadas y presentadas descriptivamente. La correlacion entre la vitamina B12 y la vitamina D/25 (OH) D se analizo mediante la prueba de correlacion de Pearson con un intervalo de confianza del 95%. Este estudio fue aprobado por el Comite de Etica Medica y de Salud, Facultad de Medicina, Universitas Gadjah Mada, Yogyakarta, Indonesia. Resultado: Todos los sujetos con EAR tienen un valor medio normal de vitamina B12 serica (453,97pg/ml + 154,44pg/ml) y un valor medio bajo de vitamina D serica/25 (OH) D (10,79 ng/ml + 3,29ng/ml) clasificado como deficiencia de vitamina D. La prueba de correlacion de Pearson mostro que habia una correlacion positiva significativa entre la vitamina B12 media y la vitamina D/25 (OH) D en suero (r=0.313, p EnglishVitamin B12 and Vitamin D deficiency may contribute to recurrent aphthous stomatitis (RAS). Current studies have showed vitamin B12 to be associated with vitamin D in women, however no study has assessed vitamin B12 associated with vitamin D/25(OH)D in women with RAS. Objective: To investigate the association between serum vitamin B12 and vitamin D/25(OH)D in women with RAS. Materials andMethods:Fourty one women with RAS who meet the inclusion criteria participated in this study. The inclusion criteria were women with RAS without other oral diseases. The exclusions criteria were those who have systemic diseases, taking medications or smoked. All subjects underwent venupuncture to draw blood to quantify serum vitamin B12 and vitamin D/25(OH)D. The characteristic of subjects, severity of RAS, serum Vitamin B12 and Vitamin D/25(OH)D were collected and presented descriptively. The correlation between vitamin B12 and Vitamin D/25(OH)D was analyzed using Pearson correlation test with 95% confidence interval. This study was approved by Medical and Health Ethics Committe, Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia. Results: All RAS subjects have normal mean value of serum Vitamin B12 (453.97pg/ml + 154.44pg/ml) and have low mean value of serum vitamin D/25(OH)D (10.79ng/ml + 3.29ng/ml) categorized as vitamin D deficiency. The Pearson correlation test showed that there was a significant positive correlation between mean serum Vitamin B12 and Vitamin D/25(OH)D (r= 0.313, p