Soluble high molecular weight derivatives of pancreatic trypsin inhibitor. Modification of pancreatic trypsin inhibitor by soluble polysaccharides activated by titanium tetrachloride

: The activation of soluble polysaccharide matrices by titan tetrachloride was studied. A method for obtaining soluble preparations of pancreatic trypsin inhibitor bound to the activated polysaccharide matrix completely retaining its inhibiting activity was developed. It was shown that the equilibrium and kinetic constants for association of modified preparations of pancreatic inhibitor with commercial trypsin did not practically differ from those for native inhibitor. It was found that modification by titan tetrachloride-activated polysaccharides stabilized the protein molecule.