Хламидийная инфекция и аспириновая бронхиальная астма

A frequency of C.pneumoniae and C.trachomatis infection was studied in 44 aspirin-induced asthma (AsBA) patients and 65 asthma patients with no aspirin intolerance (NBA) compared with certain immune system parameters and clinical course of the disease. The controls were 21 healthy persons. Each second bronchial asthma patient was found to have chronic Chlamydia infection that was confirmed by secretory IgA level >1:8. AsBA patients prevalently have IgA titre >1:32, an increased sera immune complexes level and a decreased monocyte migration inhibition index. A reduction in melatonin synthesis and associated immune disorders in AsBA patients probably facilitate the infection to transform to chronic state as soon as 91.7% of the patients younger 50 years show a high IgA-antibodies level associated with early occurrence of bronchial asthma. These data display a necessity of timely detection of Chlamydia infection and differentiated approach to antibiotics administration for asthma exacerbations in such the patients.