Association of Arterial Pressure Volume Index With the Presence of Significantly Stenosed Coronary Vessels

Background: A blood pressure (BP) monitoring system (PASESA ® ) can be used to easily analyze the characteristics of central and peripheral arteries during the measurement of brachial BP. Methods: We enrolled 108 consecutive patients (M/F = 86/22, age 70 ± 10 years) who underwent coronary angiography (CAG) due to suspected coronary artery disease (CAD) in whom we could measure various parameters using PASESA ® in addition to brachial-ankle pulse wave velocity (baPWV). The patients were divided into two groups: patients who did not have significantly stenosed coronary vessel disease (n = 33, non-SVD group) and those who had at least one significantly stenosed coronary vessel (n = 75, SVD group). The characteristics of central and peripheral arteries (arterial velocity pulse index (AVI) and arterial pressure volume index (API), respectively) and baPWV were measured. Estimated central BP (eCBP) was calculated from the data obtained from PASESA ® , and CBP was also measured simultaneously by invasive catheterization. Results: API, but not AVI and baPWV, in the SVD group was significantly higher than that in the non-SVD group. Although eCBP was significantly associated with CBP, there was no difference in eCBP between the groups. There were significant associations among API, AVI and baPWV, albeit these associations were relatively weak. A multivariate logistic regression revealed that API and β-blocker were significant independent variables that were associated with the presence of significant coronary stenosis. The cut-off level of API that gave the greatest sensitivity and specificity for the presence of SVD was 24 units (sensitivity 0.636 and specificity 0.667). Conclusion: In conclusion, API, but not AVI or baPWV, is associated with the presence of significant coronary stenosis. J Clin Med Res. 2016;8(8):598-604 doi: http://dx.doi.org/10.14740/jocmr2615w