Stereoselective Intramolecular Acylation of γ′‐Benzoyloxyphosphine Oxides with an Internal Chlorotrimethylsilane Trap: Isolation of Silylated Tetrahedral Intermediates.
2000
The kinetic products of the intramolecular acylation of γ′-benzoyloxyphosphine oxides were revealed by conducting the reaction in the presence of an internal trapping agent. A high level of stereocontrol over the formation of both the stereogenic centre α to phosphorus and the hemiacetal centre was observed. The stereochemistry of the products was determined by X-ray crystallography and 1H NMR and the stereoselectivity of the reaction is explained in terms of the known structure and configurational instability of lithiated phosphine oxides.
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