Comparison of prostatic specific antigen,prostate volume and prostatic specific antigen density in healthy Chinese males between Uygur and Han

Objective To compare the value of prostatic specific antigen(PSA),prostate volume (PV)and PSA density(PSAD)in healthy Chinese males between Uygur and Han and to analyze the relationship between age and above indexes.Methods Serum PSA of 1278 healthy Chinese men over than 40 years was measured by enzyme linked immunosorbent assay.The group composed of 555 Uygur males and 723 Han males was divided into four different age groups based on every ten years.40-49 year group: 395 (Uygur: 175,Han: 220);50-59 year group: 325(Uygur: 143,Han: 182);60-69 year group: 281(Uygur: 131,Han: 150);over than 70 year group: 277(Uygur: 106,Han: 171).The length,width and height of the prostate were measured by trans-abdominal ultrasound.The value of PSA,PV and PSAD were correlated with age using the correlation analysis.Results PSA and PV of Uygur were as follows,40 year group:(0.69 ± 0.50)μg/L,(22.83 ± 8.20)ml;50 year group:(0.87 ± 0.52)μg/L,(25.30 ± 9.27)ml;60 year group:(1.08 ±0.56)μg/L,(27.68 ±13.10)ml;70 year group:(2.39 ±0.99)μg/L,(36.36 ± 18.71)ml.PSA and PV of Han were as follows,40 year group:(1.01 ± 0.83)μg/L,(23.01 ±7.57)ml;50 year group:(1.26 ±0.80)μg/L,(27.23 ±10.24)ml;60 year group:(1.66 ±0.79)μg/L,(33.88±17.59)ml;70 year group:(2.51 ±1.11)μg/L,(43.98 ±20.21)ml.The value of PSA and PV of Uygur were less than those of Han in each age group and there were significant differences(P ＜ 0.05).PSAD of Uygur and Han in different age group were as follows: 40 year group:0.041 ± 0.022,0.042 ± 0.027;50 year group: 0.039 ± 0.027,0.040 ± 0.031;60 year group: 0.040 ±0.021,0.041 ±0.025;70 year group: 0.039 ± 0.020,0.040 ± 0.029.The PSAD showed no difference between two nationalities or any age group.With the increasing age,the value of PSA and PV gradually increased and the positive correlation was found among age,PSA and PV in both Uygar and Han nationalities.Conclusions The value of PSA and PV are affected by nationality and age.PSAD between different nationalities and age groups has no difference. Key words: Ethnic groups; Prostate specific antigen; Age factors