Construction of Recombinant Plasmid Containing Human Factor IX cDNA and Its Expression by Transfected Cells in Mice
1993
Hemophilia B is an inherited bleeding disorder due to a deficiency of factor Ⅸ.Currently, conventional therapy depends on the infusion of human plasma or factor Ⅸ concentrate. The therapeutic effect is temporary and periodic infusions are required. This approach of treatment is expensive, and is associated with a significant risk of AIDS and hepatitis. Recent advances in gene-transfer techniques have provided a new approach of therapy for genetic diseases, including factor Ⅸ deficiency. Previously, we constructed sev-
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