C4BPB/C4BPA is a new susceptibility locus for venous thrombosis with unknown protein S independent mechanism: results from genome-wide association and gene expression analyses followed by case-control studies Short title: C4BPB/C4BPA locus and risk of venous thrombosis Scientific Category: Thrombosis and Hemostasis

1 Unitat de Genomica de Malalties Complexes, Institut de Recerca Hospital de la Santa Creu i Sant Pau, Barcelona. 2 INSERM UMRS 937; Universite Pierre et Marie Curie (UPMC, Paris 6); 75013, Paris, France 3 Servei de Hematolgia. Unitat d’Hemostasia i Trombosis. Hospital de la Santa Creu i Sant Pau, Barcelona. 4 INSERM, UMR_S 626, F-13385, Marseille, France; Universite de la Mediterranee, Marseille, F-13385 France 5 Commissariat a l'Energie Atomique, Institut de Genomique, Centre National de Genotypage, Evry, France 6 Medizinische Klinik und Poliklinik, Johannes-Gutenberg Universitat Mainz, Universitatsmedizin, Langenbeckstrase 1, 55131 Mainz, Germany 7 Departamento de Inmunologia, Centro de Investigaciones Biologicas, Consejo Superior de Investigaciones Cientificas. Madrid. 8 Dalla Lana School of Public Health, University of Toronto, Ontario, M5T 3M7, Canada 9 INSERM U765, medecine vasculaire HTA, hopital europeen Georges-Pompidou, universite Paris-Descartes, Paris, France 10 Population Genetic Department. Southwest Foundation for Biomedical Research. San Antonio (TX), USA.