Effect of chronic stress during neonatal ontogeny on structural organization of the adrenal gland in hypertensive NISAG rats.

Structural organization of the adrenal gland was studied in 3-week- and 6-month-old hypertensive NISAG rats subjected to daily handling (10-min separation from mothers) on postnatal days 1-21. Neonatal handling reduces the stress-induced blood pressure rise in adult NISAG rats and modulates the structure of the adrenal cortex and medulla.