Systematic Review, An Illustration of Increased Transparency in a Framework for Evaluating Immunotoxicity Associated with PFOA and PFOS Exposure

Background: Systematic review methodologies were first developed to assess the efficacy of health care interventions, but these approaches can be adapted to evaluations of environmental health questions such as immunotoxicity associated with PFOA and PFOS exposure. This structured approach provides objectivity and transparency to the process of collecting, synthesizing, and reaching conclusions based on the scientific evidence available.