Toxicological Evaluation of Fenugreek Seeds: a Long Term Feeding Experiment in Diabetic Patients

Toxicological evaluation of fenugreek seeds was made in 60 NIDDM subjects in a 24 week study in which changes in body weight, clinical signs and symptoms and serum parameters such as SGOT, SGPT, alkaline phosphatase, bilirubin, creatinine and blood urea, together with haematological parameters, was studied. Ingestion of an experimental diet containing 25 g fenugreek seed powder resulted in no renal or hepatic toxicity, but interestingly blood urea levels were seen to decrease after week 12.