CHALCONES FROM Desmodium podocarpum AND THEIR CYTOTOXICITY

Two new chalcones, 2 ,4-hydroxy-3,4 -dimethoxychalcone (1) and 2 ,3-hydroxy-4,4 -dimethoxychalcone (2), together with four known chalcones (3–6), were isolated from the whole plant of Desmodium podocarpum. All of their structures were determined by spectroscopic methods including 1D and 2D NMR. Compounds 1 and 2 were evaluated for their cytotoxicity using five tumor cell lines. Compound 1 exhibited cytotoxicity against SHSY5Y and PC3 cells with IC50 values of 3.8 and 3.6 M, and compound 2 exhibited cytotoxicity against A549 cells with IC50 value of 3.5 M, respectively.