Metabolomics approach for male lower urinary tract symptoms: An identification of possible biomarkers and potential targets for new treatments

Purpose: We identified metabolites using a metabolomics approach and investigated the association between these metabolites and lower urinary tract symptoms.Materials and Methods: We used a 24-hour bladder diary and I-PSS (International Prostate Symptom Score) to assess micturition behavior and lower urinary tract symptoms in 58 male patients without apparent neurological disease. Lower urinary tract symptoms were defined as a total I-PSS score of 8 or greater. Patients with a score of 7 or less were placed in the control group. A comprehensive study of plasma metabolites was also performed by capillary electrophoresis time-of-flight mass spectrometry. Metabolites were compared between the lower urinary tract symptoms and control groups using the Mann-Whitney U test. Biomarkers of male lower urinary tract symptoms from the metabolites were analyzed using multivariable logistic regression analysis to determine the OR.Results: Of the 58 men 32 were in the lower urinary tract symptoms group and the remaining...