[Cyclosporin, toxicity and efficacy in rejection of liver allografts in the rat].

52 orthotopic liver transplants were performed in DA to lewis rat strain combination, in order to appreciate ciclosporin toxicity, and efficacy at doses of 10 mg/kg day (G II) and 20 mg/kg/day (GIII) compared to liver allografts in DA/lewis rats. In spite of renal and hepatic toxicity, ciclosporin by itself, allows the abolition of the acute rejection of liver allografts in the rat