PD14-02 IN VIVO SELECTIVITY OF DA-8010 FOR THE BLADDER OVER THE BRAIN: EFFECTS ON BLADDER INTRAVESICAL PRESSURE, BRAIN MUSCARINIC RECEPTOR OCCUPANCY, AND COGNITIVE FUNCTION IN MICE

INTRODUCTION AND OBJECTIVES:Antimuscarinic agents are widely used as the first line therapy for overactive bladder (OAB). However, concerns have emerged about side effects of antimuscarinics in cen...