ω-Conotoxin MVIIC reversibly inhibits a human N-type calcium channel and calcium influx into chick synaptosomes

Abstract We have investigated the effects of ω-CmTX MVIIC on the recombinant α 1B -mediated calcium channel expressed in HEK 293 cells and on the predominantly N-type calcium channel in chick synaptosomes. ω-CmTX MVIIC potently and reversibly inhibited the calcium current through α 1B -mediated calcium channels and inhibited KCl-evoked increases in [Ca 2+ ] i , in chick synaptosomes in a concentration-dependent manner.