P-PN031. Medicinal importance and health beneficial effect of tangeretin: Therapeutic role in neurodegeneration and inflammatory responses

Introduction. Citrus flavonoids are important polyphenolic compounds having huge biological potential. Therapeutic potential of various flavonoidal compounds in obesity, cancer, diabetes and Alzheimer’s has been well documented in the scientific literature. Demand of natural products and their derived products including dietary supplements has been increased in the medical field. Alzheimer’s and Parkinson's disease are most common Neurodegenerative disorders affecting huge population in the world. Prevention and treatment of neurodegenerative disorders by use of natural products is warranted. Tangeretin is important polymethoxylated flavonoids derived from the peel and other parts of Citrus fruits. Tangeretin has been proven for their antiinflammatory and neuroprotective effects in several disorders. Methods. To know the therapeutic importance of tangeretin in the medicine, various scientific databases have been searched and evaluated for their role in neurodegeneration and inflammatory responses. Medicinal importance and therapeutic effect of tangeretin in neurodegeneration and related disorders have been analyzed through different scientific database. Therapeutic importance of tangeretin in neurodegeneration and inflammatory disorders has been analyzed in the present study and correlated with other biological potential. Results. From the analysis of the scientific databases of tangeretin it was found to have chemopreventive and neuroprotective potential. Scientific data analysis revealed that tangeretin reduced expression of inflammatory mediators. Experimental databases suggest that tangeretin is an effective candidate for prevention and treatment of neuroinflammation and dementia. Other experimental study suggests that tangeretin decreased nitric oxide. Tangeretin is also effective in colitis through suppression of IL12 and TNF-α expression and nuclear factor kappa-B activation. Conclusion. From the analysis of the scientific research work it was found that tangeretin have potential medicinal value for the treatment of neurodegeneration and inflammatory medicated disorders.