Herstellung und Analytik eines in der Krankenhausapotheke hergestellten Paclitaxel-Infusionslösungskonzentrats

The production of Paclitaxel injection in the hospital pharmacy represents a very interesting possibility to reduce therapy costs at a high quality level. The composition, production, quality control methods and stabilitytesting of paclitaxel injection are described. We monitored the stability of the injection solution at light protected storage at < -20 °C over a period of 12 weeks. The decomposition rate of Paclitaxel at this temperature was very low, so that the amount after this time was 98,63 % of the initial value and the product conforms the specification. The long-term stability study continues. The quality of the Paclitaxel injection produced in the hospital pharmacy was found to be at the same level as the industrial products.