The epidemiological profile of hospitalized acquired infections (HAIs) due to multidrug-resistant (MDR) pathogens in patients with hematological malignancies and solid neoplasms: “Real World” experience of a single cancer hospital.

e13104Background: Isolates of pathogens that are resistant to all, or almost all, commercially available antibiotics are now prevalent worldwide. The increasing frequency of MDR pathogens is concerning as efficacious antimicrobial options are severely limited. Methods: We conducted a descriptive study including all notified cases of HAIs due to MDR organisms in patients with hematological malignancies and solid tumors, that between January 2014 and December 2015. We described case-patients with HAIs in terms of the clinic in which the infection was diagnosed, pathogen which caused the nosocomial infection and the site of infection in relation with the positive cultures obtained to verify it. Results: Overall, 425 case-patients were studied. The most frequently reported multidrug-resistant organisms were: Klebsiella pneumoniae KPC (50%), Clostridium difficile (11%), VRE Enterococcus faecium (10%), Pseudomonas aeruginosa MBL (8%), Klebsiella pneumoniae MBL (6%), Acinetobacter Baumanii (5%), Acinetobacter Ba...