SARS-CoV-2 And Trojan Horse Phenomenon -Caveat In Vaccine Quest?

One of the fears that grapples the success of these vaccines is the phenomenon of antibody dependent Enhancement (ADE) or more historically vivid- Trojan Horse phenomenon. The concept of ADE was given in 1964 by Hawkes et al. who in vitro experiments demonstrated increased infectivity of Murray Valley encephalitis virus in the presence of antibodies.