Expression of T-Cell Receptor by a Mouse Monoclonal Antigen-Specific Suppressor T-Cell Line

The antigen receptor expressed by mouse T lymphocytes is composed of a disul- fide-linked dimer of about 85K, resolved under reducing conditions in two sub-units with an apparent Mr of approximately 42K (Allison et al. 1982; Kappler et al. 1983). The antigen-specific receptor expressed by human T lymphocytes displays a similar structure, but the two subunits, denominated α and β chain, have a Mr of about 51K and 43K, respectively (Meuer et al. 1983; Acuto et al. 1983).