Gidazepam biotransformation and pharmacokinetics in different species of animals and man
1993
: The biotransformation and pharmacokinetics of the new tranquilizer gidazepam were studied after its single oral administration in rats, rabbits, monkeys and man. The significant interspecies differences in gidazepam metabolism were found. Some pharmacokinetic parameters of gidazepam and its major metabolite desalkylgidazepam were determined. It was assumed that desalkylgidazepam as gidazepam in rabbits and monkeys might contribute to the formation of pharmacological effects, in rats and man its pharmacological action was realized entirely by virtue of desalkylgidazepam.
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