[Knockdown of interleukin 20 receptor 2 (IL-20R2) inhibits the development of psoriasis induced by imiquimod in mice].

: Objective To investigate the role of interleukin 20 receptor 2 (IL-20R2) family signaling pathway in psoriasis via imiquimod (IMQ) treatment. Methods IL-20R2 knockdown (IL-20R2-/-) mice and wild type IL-20R2+/+mice were used in this experiment. IL-20R2 mRNA in the skin tissue of the mice was detected by PCR sequencing and the IL-20R2 protein level was analyzed by Western blot analysis. We then established a psoriasis-like mouse model by topical treatment with IMQ, and body mass and skin lesions were recorded daily. In addition, HE staining was performed to observe the pathological changes of the skin. Results Compared with wild type IL-20R2+/+mice, the IL-20R2-/- mice showed lower levels of both IL-20R2 protein and mRNA in the skin tissue, also exhibited a markedly less pathological changes after IMQ induction. Conclusion Knockdown of IL-20R2 gene can inhibit the development of psoriasis induced by IMQ in mice.