Lysophosphatidylserine as an Inflammatory Mediator

Lysophosphatidylserine (LysoPS), a deacylated form of phosphatidylserine (PS), has been assumed to serve as a bioactive lysophospholipid mediator. However, LysoPS has received little attention because its mode of actions as well as its synthetic pathways have been obscure. Recently G protein-coupled receptors (GPCRs) specific for LysoPS, and enzymes responsible for the generation of LysoPS have been identified. These LysoPS-related molecules are mainly expressed on immune cells, which led us to assume that LysoPS may have some roles in inflammation. Here we summarised the newly discovered LysoPS receptors and enzymes including our recent works.