Three-dimensional Propagation in Mathematic Models: Integrative Model of the Mouse Heart

Computer models have been used to study cardiac conduction since the late 1970s. 1 At that time, computational power limited investigations to simple geometries corresponding to single fibers or monolayer sheets of cells. With the evolution of computer technologies, computational models of the heart have become three-dimensional and increasingly more realistic, 2 3 4 allowing a wider range of investigations to elucidate fundamental relations of a set of biophysic parameters and the underlying potential distributions and current flow.