Effect of Photomodulation Therapy on Development of Oxidative Stress in Blood Leukocytes of Rats with Streptozocin-Induced Diabetes Mellitus

Abstract—Oxidative stress is among the main causes of developing severe complications in diabetes mellitus (DM). Existing pharmaceuticals, although efficient in reducing the blood glucose level, infrequently demonstrate antioxidant properties. On the other hand, there are many reliable reports about a broad range of biological activity exhibited by photobiomodulation therapy (PBMT). Its potential sugar-lowering and antioxidant action makes this type of therapy a promising option for the treatment of DM and its complications. The effect of PBMT on the state of the antioxidant defense system in blood leukocytes was investigated in rats with streprozocin-induced DM. This study has shown that the PBMT increased superoxide dismutase (SOD) activity in rats with DM and normalized the content of oxidative stress markers (thiobarbituric acid (TBA)-active products, oxidatively modified proteins, and protein glycation end products).