Effect of (S)-3,5-DHPG on learning, exploratory activity and anxiety in rats with experimental hypoxia.

In hypoxia-treated groups of rats, (S)-3,5-DHPG inhibited locomotor and exploratory activity in comparison with the control groups administered (S)-3,5-DHPG. Hypoxia significantly inhibited beneficial effects of (S)-3,5-DHPG on consolidation and retrieval in passive avoidance. (S)-3,5-DHPG only at the dose of 1.0 nmol used before hypoxia improved consolidation and at the dose of 0.01 nmol enhanced retrieval in comparison with saline-treated group subjected to hypoxia. (S)-3,5-DHPG only at the dose of 1.0 nmol in hypoxia-treated group shortened the time spent in closed arms and increased the number of entries into closed and open arms in the elevated “plus” maze vs saline-treated group subjected to hypoxia. In rats subjected to hypoxia, (S)-3,5-DHPG, the agonist of I mGluRs, improved consolidation and retrieval and exhibited anxiolytic activity in dose-dependent manner.