Drug protein interaction: displacement of albumin bound 8-methoxypsoralen by drugs.

The displacement of 8-methoxypsoralen (8-MOP) bound to albumin by a number of drugs commonly used in therapy was investigated by equilibrium dialysis, using tritium labelled furocoumarin. Furocoumarin binding was found to be influenced by several compounds. However because of the concentrations of furocoumarin and displacers reached in plasma, only tolbutamide could modify the 8-MOP binding to a pharmacokinetically significant extent.