The study of the effects of the combination of Himantane and Piribedil on a model of MPTP-induced parkinsonian syndrome in C57BL/6 mice

The effectiveness of hemantane, an original adamantane derivative, in combination with the dopamine receptor agonist piribedil on the model of acute parkinsonian syndrome induced by a single intraperitoneal injection of 30 mg/kg neurotoxicin-1, induced by a single intraperitoneal injection of 30 mg/kg neurotoxin 1-methyl-4-phenyl-tetrahydropyridine (MPTP) in C57BL/6 mice. Rigidity was assessed by stride length, oligokinesia and impaired coordination in the “rotarod test’’, effect on the catalepsy model caused by 0.1 mg/kg haloperidol. It has been established that the combination of hemantane and piribedil reduces the manifestations of parkinsonian syndrome, significantly exceeding in efficiency of each of the drugs separately.