Qualitative analysis and reproducibility assessment of the Scalp Itch Numeric Rating Scale among patients with moderate to severe plaque psoriasis of the scalp

AbstractBackground: Pruritus is a prevalent and bothersome symptom of scalp psoriasis. Validated scales assessing scalp itch are needed to evaluate treatment efficacy.Objective: To evaluate comprehensibility and reproducibility of the Scalp Itch Numeric Rating Scale (NRS), a novel scale being used in a phase 3 study of apremilast.Methods: The Scalp Itch NRS, Modified Whole Body Itch NRS, Global Assessment of Psoriasis Severity-Scalp (GAPS-S), and Global Impression of Change-Scalp Itch (GIC-SI) were assessed among patients with moderate to severe scalp psoriasis. Convergent validity and test–retest reliability between two visits (7 ± 3 days apart) were assessed using intra-class and Spearman’s correlations.Results: Patients found the Scalp Itch NRS easy to use and understand. Convergent validity (Modified Whole Body Itch NRS Visit 1: rs = 0.71, Visit 2: rs = 0.92, p< .0001; GAPS-S Visit 1: rs = 0.62, Visit 2: rs = 0.63, p< .0001), and consistency with changes (Modified Whole Body Itch NRS: rs = 0.69, p< .0...