Synthesis, antimicrobial, anticancer evaluation and QSAR studies of 2/3-bromo-N′-(substituted benzylidene/3-phenylallylidene)benzohydrazides

Abstract In the present study, a series of 2/3-bromo- N′ -(substituted benzylidene/3-phenylallylidene)benzohydrazides was synthesized and evaluated in vitro for its antimicrobial and anticancer potentials . The results of antimicrobial and anticancer study indicated that compounds 3 , 15 and 18 (pMIC am  = 1.62 μM/ml) were found to be most potent antimicrobial agents and compound 4 (IC 50  = 1.88 ± 0.03 μM) was found to be the most potent anticancer agent. The results of QSAR analysis indicated the importance of topological parameters, Balaban index ( J ) and valence first and second order molecular connectivity indices ( 1 χ v and 2 χ v ) in describing antimicrobial activity of the synthesized benzohydrazides.