Measurement and correlation of the solubility of estradiol and estradiol-urea co-crystal in fourteen pure solvents at temperatures from 273.15 K to 318.15 K

Abstract The solubility of estradiol and estradiol-urea co-crystal in fourteen pure solvents had been measured at temperatures from 273.15 K to 318.15 K. The solubility of estradiol and estradiol-urea co-crystal in fourteen pure solvents increased with increasing temperature. The solubility data of estradiol in fourteen solvents were fitted by the modified Apelblat equation, Van't Hoff equation, λh equation, NRTL equation, and Wilson equation. The solubility data of estradiol-urea co-crystal in fourteen solvents were fitted by the modified Apelblat equation, Van't Hoff equation, λh equation. The solubility values obtained by the correlation of the above thermodynamic models are in agree with the experimental values. The experimental data is very useful for the application of estradiol.