D2 dopamine receptor internalization prolongs the decrease of radioligand binding after amphetamine: A PET study in a receptor internalization-deficient mouse model

Mette Skinbjerg,Jeih-San Liow,Nicholas Seneca,Jinsoo Hong,Shuiyu Lu,Annika Thorsell,Markus Heilig,Victor W. Pike,Christer Halldin,David R. Sibley,Robert B. Innis

D2 dopamine receptor internalization prolongs the decrease of radioligand binding after amphetamine: A PET study in a receptor internalization-deficient mouse model

2010

Mette Skinbjerg
Jeih-San Liow
Nicholas Seneca
Jinsoo Hong
Shuiyu Lu
Annika Thorsell
Markus Heilig
Victor W. Pike
Christer Halldin
David R. Sibley
Robert B. Innis

Dopamine released by amphetamine decreases the in vivo binding of PET radioligands to the dopamine D(2) receptor. Although concentrations of extracellular dopamine largely return to baseline within ...

Keywords:

Psychology
Internalization
Dopamine
Dopamine receptor D2
Dopamine receptor
Dopamine receptor D1
Internal medicine
Endocrinology
Receptor
Radioligand
Amphetamine
In vivo

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