1362 NOCTURIA CORRELATES WITH BLADDER AND SYSTEMIC ISSUES AND INCREASES MORTALITY IN PATIENTS WITH TYPE 2 DIABETES

INTRODUCTION AND OBJECTIVES: Nocturia has been associated with overactive bladder (OAB). We evaluate the correlates of nocturia independent of OAB, and subsequent mortality in patients with type 2 diabetes. METHODS: A self-administered questionnaire containing OAB symptom score (including nocturia score 0-3) was obtained from subjects with type 2 diabetes at a dedicated diabetic center. Nocturia and severe nocturia were defined as rising 2 or more times per night to void, and rising 3 or more times per night to void, respectively. Patient characteristics and diabetes associated complications to risk of nocturia were evaluated. RESULTS: Of 1,301 consecutive subjects, 59.6% and 25.3% reported having nocturia and severe nocturia, respectively. The presence and severity of nocturia increased with age. After adjustment for age, duration of DM and the presence of OAB, stroke, calcium channel blocker use, hypertension, abnormal waist circumference, diabetic kidney disease (albuminuria, high serum creatinine level, and low eGFR), and higher level of hsCRP, were associated with nocturia and severe nocturia. Higher BMI and female gender are risk factors for nocturia, and coronary heart disease and higher level of uric acid are risk factors for severe nocturia. The patients with severe nocturia has higher mortality rate than the other group (6.1% vs 2.4%, p 0.001) in 3 years follow-up. CONCLUSIONS: Nocturia is highly prevalent in type 2 diabetes. Systemic factors including stroke, hypertension, obesity and diabetic kidney disease are risk factors of nocturia independent of OAB. Severe nocturia increases mortality rate and bladder dysfunction may not be the only cause of nocturia. Source of Funding: Kaohsung Chang Gung Memorial Hospital, Taiwan, CMRPG 860381.