Actinin, alpha 1

2EYI, 2EYN, 2N8Z, 2N8Y87109711ENSG00000072110ENSMUSG00000015143P12814Q7TPR4NM_001102NM_001130004NM_001130005NM_134156NM_001346669NP_001093NP_001123476NP_001123477NP_001093.1NP_001333598NP_598917Alpha-actinin-1 is a protein that in humans is encoded by the ACTN1 gene.1sjj: Cryo-EM Structure of Chicken Gizzard Smooth Muscle alpha-Actinin2eyi: Crystal structure of the actin-binding domain of human alpha-actinin 1 at 1.7 Angstrom resolution2eyn: Crystal structure of the actin-binding domain of human alpha-actinin 1 at 1.8 Angstrom resolution Alpha-actinin-1 is a protein that in humans is encoded by the ACTN1 gene. Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Actinin, alpha 1 has been shown to interact with: