RNF128

3ICU7958966889ENSG00000133135ENSMUSG00000031438Q8TEB7Q9D304NM_194463NM_024539NM_001254761NM_023270NP_078815NP_919445NP_001241690NP_075759E3 ubiquitin-protein ligase RNF128 is an enzyme that in humans is encoded by the RNF128 gene. E3 ubiquitin-protein ligase RNF128 is an enzyme that in humans is encoded by the RNF128 gene. The protein encoded by this gene is a type I transmembrane protein that localizes to the endocytic pathway. This protein contains a RING zinc-finger motif and has been shown to possess E3 ubiquitin ligase activity. Expression of this gene in retrovirally transduced T cell hybridoma significantly inhibits activation-induced IL2 and IL4 cytokine production. Induced expression of this gene was observed in anergic CD4(+) T cells, which suggested a role in the induction of anergic phenotype. Alternatively spliced transcript variants encoding distinct isoforms have been reported. RNF128 has been shown to interact with CD154 and OTUB1.