Antrodia serialis is a species of polypore fungus in the genus Antrodia. Originally named Polyporus serialis by Elias Fries in 1821, it was given its current name by Marinus Anton Donk in 1966. A widespread species, A. serialis causes heart rot in living trees. In North America, it is often confused with the morphologically similar Antrodia serialiformis, which grows on oak.