SGCA

644220391ENSG00000108823ENSMUSG00000001508Q16586P82350NM_000023NM_001135697NM_009161NP_000014NP_001129169NP_033187Alpha-sarcoglycan is a protein that in humans is encoded by the SGCA gene. Alpha-sarcoglycan is a protein that in humans is encoded by the SGCA gene. The dystrophin-glycoprotein complex (DGC) comprises a group of proteins that are critical to the stability of muscle fiber membranes and to the linking of the actin cytoskeleton to the extracellular matrix. Components of the DGC include dystrophin (MIM 300377), which is deficient in Duchenne muscular dystrophy (DMD; MIM 310200); syntrophins (e.g., MIM 600026); dystroglycans (MIM 128239); and sarcoglycans, such as adhalin, a 50-kD transmembrane protein (Roberds et al., 1993). SGCA has been shown to interact with Biglycan.