MAD1L1

4DZO, 1GO4837917120ENSG00000002822ENSMUSG00000029554Q9Y6D9Q9WTX8NM_003550NM_010752NM_001359025NM_001359027NP_003541NP_034882NP_001345954NP_001345956Mitotic spindle assembly checkpoint protein MAD1 is a protein that in humans is encoded by the MAD1L1 gene.1go4: CRYSTAL STRUCTURE OF MAD1-MAD2 REVEALS A CONSERVED MAD2 BINDING MOTIF IN MAD1 AND CDC20. Mitotic spindle assembly checkpoint protein MAD1 is a protein that in humans is encoded by the MAD1L1 gene. MAD1L1 is also known as Human Accelerated Region 3. It may therefore have played a key role in differentiating Humans from Apes. MAD1L1 is a component of the mitotic spindle-assembly checkpoint that prevents the onset of anaphase until all chromosome are properly aligned at the metaphase plate. MAD1L1 functions as a homodimer and interacts with MAD2L1. MAD1L1 may play a role in cell cycle control and tumor suppression. Three transcript variants encoding the same protein have been found for this gene. MAD1L1 has been shown to interact with: