Earthquake prediction is a branch of the science of seismology concerned with the specification of the time, location, and magnitude of future earthquakes within stated limits, and particularly 'the determination of parameters for the next strong earthquake to occur in a region. Earthquake prediction is sometimes distinguished from earthquake forecasting, which can be defined as the probabilistic assessment of general earthquake hazard, including the frequency and magnitude of damaging earthquakes in a given area over years or decades. Prediction can be further distinguished from earthquake warning systems, which upon detection of an earthquake, provide a real-time warning of seconds to neighboring regions that might be affected. In the 1970s, scientists were optimistic that a practical method for predicting earthquakes would soon be found, but by the 1990s continuing failure led many to question whether it was even possible. Demonstrably successful predictions of large earthquakes have not occurred and the few claims of success are controversial. For example, the most famous claim of a successful prediction is that alleged for the 1975 Haicheng earthquake. A later study said that there was no valid short-term prediction. Extensive searches have reported many possible earthquake precursors, but, so far, such precursors have not been reliably identified across significant spatial and temporal scales. While part of the scientific community hold that, taking into account non-seismic precursors and given enough resources to study them extensively, prediction might be possible, most scientists are pessimistic and some maintain that earthquake prediction is inherently impossible. Predictions are deemed significant if they can be shown to be successful beyond random chance. Therefore, methods of statistical hypothesis testing are used to determine the probability that an earthquake such as is predicted would happen anyway (the null hypothesis). The predictions are then evaluated by testing whether they correlate with actual earthquakes better than the null hypothesis. In many instances, however, the statistical nature of earthquake occurrence is not simply homogeneous. Clustering occurs in both space and time. In southern California about 6% of M≥3.0 earthquakes are 'followed by an earthquake of larger magnitude within 5 days and 10 km.' In central Italy 9.5% of M≥3.0 earthquakes are followed by a larger event within 48 hours and 30 km. While such statistics are not satisfactory for purposes of prediction (giving ten to twenty false alarms for each successful prediction) they will skew the results of any analysis that assumes that earthquakes occur randomly in time, for example, as realized from a Poisson process. It has been shown that a 'naive' method based solely on clustering can successfully predict about 5% of earthquakes; 'far better than 'chance''. As the purpose of short-term prediction is to enable emergency measures to reduce death and destruction, failure to give warning of a major earthquake, that does occur, or at least an adequate evaluation of the hazard, can result in legal liability, or even political purging. For example, it has been reported that members of the Chinese Academy of Sciences were purged for 'having ignored scientific predictions of the disastrous Tangshan earthquake of summer 1976.' Wade 1977. Following the L'Aquila earthquake of 2009, seven scientists and technicians in Italy were convicted of manslaughter, but not so much for failing to predict the 2009 L'Aquila Earthquake (where some 300 people died) as for giving undue assurance to the populace – one victim called it 'anaesthetizing' – that there would not be a serious earthquake, and therefore no need to take precautions. But warning of an earthquake that does not occur also incurs a cost: not only the cost of the emergency measures themselves, but of civil and economic disruption. False alarms, including alarms that are canceled, also undermine the credibility, and thereby the effectiveness, of future warnings. In 1999 it was reported (Saegusa 1999) that China was introducing 'tough regulations intended to stamp out ‘false’ earthquake warnings, in order to prevent panic and mass evacuation of cities triggered by forecasts of major tremors.' This was prompted by 'more than 30 unofficial earthquake warnings ... in the past three years, none of which has been accurate.' The acceptable trade-off between missed quakes and false alarms depends on the societal valuation of these outcomes. The rate of occurrence of both must be considered when evaluating any prediction method. In a 1997 study of the cost-benefit ratio of earthquake prediction research in Greece, Stathis Stiros suggested that even a (hypothetical) excellent prediction method would be of questionable social utility, because 'organized evacuation of urban centers is unlikely to be successfully accomplished', while 'panic and other undesirable side-effects can also be anticipated.' He found that earthquakes kill less than ten people per year in Greece (on average), and that most of those fatalities occurred in large buildings with identifiable structural issues. Therefore, Stiros stated that it would be much more cost-effective to focus efforts on identifying and upgrading unsafe buildings. Since the death toll on Greek highways is more than 2300 per year on average, he argued that more lives would also be saved if Greece's entire budget for earthquake prediction had been used for street and highway safety instead. Earthquake prediction is an immature science—it has not yet led to a successful prediction of an earthquake from first physical principles. Research into methods of prediction therefore focus on empirical analysis, with two general approaches: either identifying distinctive precursors to earthquakes, or identifying some kind of geophysical trend or pattern in seismicity that might precede a large earthquake. Precursor methods are pursued largely because of their potential utility for short-term earthquake prediction or forecasting, while 'trend' methods are generally thought to be useful for forecasting, long term prediction (10 to 100 years time scale) or intermediate term prediction (1 to 10 years time scale). An earthquake precursor is an anomalous phenomenon that might give effective warning of an impending earthquake. Reports of these – though generally recognized as such only after the event – number in the thousands, some dating back to antiquity. There have been around 400 reports of possible precursors in scientific literature, of roughly twenty different types, running the gamut from aeronomy to zoology. None have been found to be reliable for the purposes of earthquake prediction.