Single-ended signaling is the simplest and most commonly used method of transmitting electrical signals over wires. One wire carries a varying voltage that represents the signal, while the other wire is connected to a reference voltage, usually ground. Single-ended signaling is the simplest and most commonly used method of transmitting electrical signals over wires. One wire carries a varying voltage that represents the signal, while the other wire is connected to a reference voltage, usually ground. The main alternative to single-ended signaling is called differential signaling. There is also the historic alternative of ground return, rarely used today.