HLA-DR1

HLA-DR1 (DR1) is a HLA-DR serotype that recognizes the DRB1*01 gene products. HLA-DR1 (DR1) is a HLA-DR serotype that recognizes the DRB1*01 gene products. The serology for the most common DR1 alleles is excellent. The serology for alleles *0104, *0106, *0109, *0110, *0112, *0115, and *0116 is unknown. DR1 is associated seronegative-rheumatoid arthritis, penicillamine-induced myasthenia, and schizophrenia. DR1 is increased in patients with systemic sclerosis and arthritis and in ulcerative colitis with patients that have articular manifestations. DRB1*0101 is associated with rheumatoid arthritis, in anti-Jk(a) mediated hemolytic transfusion reactions, foliaceous pemphigus, HTLV-1-associated myelopathy/tropical spastic paraparesis, and lichen planus. In lyme disease arthritis, *0101 appears to play a role inpresentation of triggering microbial antigens. DRB1*0102 is associated with rheumatoid arthritis, in anti-Jk(a) mediated hemolytic transfusion reactions, psoriasis vulgaris, and recurrent respiratory papillomatosis DRB1*0103 is associated with colonic Crohn's disease and ulcerative colitis. DRB1*0101/*0404 and *0101/*0401 increases risk of mortality in rheumatoid arthritis, with eschemic heart disease and smoking. these same genotypes are associated with rheumatoid vasculitis. DRB1*0102:DQB1*0501 is associated with psoriasis vulgaris and tubulointerstitial nephritis & uveitis syndrome, but is relatively protective against juvenile diabetes. DR1-DQ5 is associate with tubulointerstitial nephritis & uveitis syndrome.