Ancient Greek medicine was a compilation of theories and practices that were constantly expanding through new ideologies and trials. Many components were considered in ancient Greek medicine, intertwining the spiritual with the physical. Specifically, the ancient Greeks believed health was affected by the humors, geographic location, social class, diet, trauma, beliefs, and mindset. Early on the ancient Greeks believed that illnesses were 'divine punishments' and that healing was a 'gift from the Gods'. As trials continued wherein theories were tested against symptoms and results, the pure spiritual beliefs regarding 'punishments' and 'gifts' were replaced with a foundation based in the physical, i.e., cause and effect. Ancient Greek medicine was a compilation of theories and practices that were constantly expanding through new ideologies and trials. Many components were considered in ancient Greek medicine, intertwining the spiritual with the physical. Specifically, the ancient Greeks believed health was affected by the humors, geographic location, social class, diet, trauma, beliefs, and mindset. Early on the ancient Greeks believed that illnesses were 'divine punishments' and that healing was a 'gift from the Gods'. As trials continued wherein theories were tested against symptoms and results, the pure spiritual beliefs regarding 'punishments' and 'gifts' were replaced with a foundation based in the physical, i.e., cause and effect. Humorism (or the four humors) refers to blood, phlegm, yellow bile and black bile. It was also theorized that sex played a role in medicine because some diseases and treatments were different for females than for males. Moreover, geographic location and social class affected the living conditions of the people and might subject them to different environmental issues such as mosquitoes, rats, and availability of clean drinking water. Diet was thought to be an issue as well and might be affected by a lack of access to adequate nourishment. Trauma, such as that suffered by gladiators, from dog bites or other injuries, played a role in theories relating to understanding anatomy and infections. Additionally, there was significant focus on the beliefs and mindset of the patient in the diagnosis and treatment theories. It was recognized that the mind played a role in healing, or that it might also be the sole basis for the illness. Ancient Greek medicine began to revolve around the theory of humors.The humoral theory states that good health comes from a perfect balance of the four humors: blood, phlegm, yellow bile, and black bile. Consequently, poor health resulted from improper balance of the four humors. Hippocrates, known as the 'Father of Modern Medicine', established a medical school at Cos and is the most important figure in ancient Greek medicine. Hippocrates and his students documented numerous illnesses in the Hippocratic Corpus, and developed the Hippocratic Oath for physicians, which is still in use today. The contributions to ancient Greek medicine of Hippocrates, Socrates and others had a lasting influence on Islamic medicine and medieval European medicine until many of their findings eventually became obsolete in the 14th century. The earliest known Greek medical school opened in Cnidus in 700 BC. Alcmaeon, author of the first anatomical compilation, worked at this school, and it was here that the practice of observing patients was established. Despite their known respect for Egyptian medicine, attempts to discern any particular influence on Greek practice at this early time have not been dramatically successful because of the lack of sources and the challenge of understanding ancient medical terminology. It is clear, however, that the Greeks imported Egyptian substances into their pharmacopoeia, and the influence became more pronounced after the establishment of a school of Greek medicine in Alexandria. Asclepius was espoused as the first physician, and myth placed him as the son of Apollo.Temples dedicated to the healer-god Asclepius, known as Asclepieia (Greek: Ἀσκληπιεῖα; sing. Ἀσκληπιεῖον Asclepieion), functioned as centers of medical advice, prognosis, and healing. At these shrines, patients would enter a dream-like state of induced sleep known as 'enkoimesis' (Greek: ἐγκοίμησις) not unlike anesthesia, in which they either received guidance from the deity in a dream or were cured by surgery. Asclepeia provided carefully controlled spaces conducive to healing and fulfilled several of the requirements of institutions created for healing. The Temple of Asclepius in Pergamum had a spring that flowed down into an underground room in the Temple. People would come to drink the waters and to bathe in them because they were believed to have medicinal properties. Mud baths and hot teas such as chamomile were used to calm them or peppermint tea to soothe their headaches, which is still a home remedy used by many today. The patients were encouraged to sleep in the facilities too. Their dreams were interpreted by the doctors and their symptoms were then reviewed. Dogs would occasionally be brought in to lick open wounds for assistance in their healing. In the Asclepieion of Epidaurus, three large marble boards dated to 350 BC preserve the names, case histories, complaints, and cures of about 70 patients who came to the temple with a problem and shed it there. Some of the surgical cures listed, such as the opening of an abdominal abscess or the removal of traumatic foreign material, are realistic enough to have taken place, but with the patient in a state of enkoimesis induced with the help of soporific substances such as opium. The Rod of Asclepius is a universal symbol for medicine to this day. However, it is frequently confused with Caduceus, which was a staff wielded by the god Hermes. The Rod of Asclepius embodies one snake with no wings whereas Caduceus is represented by two snakes and a pair of wings depicting the swiftness of Hermes. Ancient Greek physicians regarded disease as being of supernatural origin, brought about from the dissatisfaction of the gods or from demonic possession. The fault of the ailment was placed on the patient and the role of the physician was to conciliate with the gods or exorcise the demon with prayers, spells, and sacrifices. The Hippocratic Corpus opposes ancient beliefs, offering biologically based approaches to disease instead of magical intervention. The Hippocratic Corpus is a collection of about seventy early medical works from ancient Greece that are associated with Hippocrates and his students. Although once thought to have been written by Hippocrates himself, many scholars today believe that these texts were written by a series of authors over several decades. The Corpus contains the treatise, the Sacred Disease, which argues that if all diseases were derived from supernatural sources, biological medicines would not work. The establishment of the humoral theory of medicine focused on the balance between blood, yellow and black bile, and phlegm in the human body. Being too hot, cold, dry or wet disturbed the balance between the humors, resulting in disease and illness. Gods and demons were not believed to punish the patient, but attributed to bad air (miasma theory). Physicians who practiced humoral medicine focused on reestablishing balance between the humors. The shift from supernatural disease to biological disease did not completely abolish Greek religion, but offered a new method of how physicians interacted with patients. Ancient Greek physicians who followed humorism emphasized the importance of environment. Physicians believed patients would be subjected to various diseases based on the environment they resided. The local water supply and the direction the wind blew influenced the health of the local populace. Patients played an important role in their treatment. Stated in the treatise 'Aphorisms', 't is not enough for the physician to do what is necessary, but the patient and the attendant must do their part as well'. Patient compliance was rooted in their respect for the physician. According to the treatise 'Prognostic', a physician was able to increase their reputation and respect through 'prognosis', knowing the outcome of the disease. Physicians had an active role in the lives of patients, taking into consideration their residence. Distinguishing between fatal diseases and recoverable disease was important for patient trust and respect, positively influencing patient compliance.