PARK7

1J42, 1P5F, 1PDV, 1PDW, 1PE0, 1Q2U, 1SOA, 1UCF, 2OR3, 2R1T, 2R1U, 2R1V, 2RK3, 2RK4, 2RK6, 3B36, 3B38, 3B3A, 3BWE, 3CY6, 3CYF, 3CZ9, 3CZA, 3EZG, 3F71, 3SF8, 4BTE, 4MNT, 4MTC, 4N0M, 4N12, 4OGF, 4OQ4, 4P2G, 4P34, 4P35, 4P36, 4ZGG, 4RKW, 4RKY, 4S0Z1131557320ENSG00000116288ENSMUSG00000028964Q99497Q99LX0NM_001123377NM_007262NM_020569NP_001116849NP_009193NP_065594Protein deglycase DJ-1, also known as Parkinson disease protein 7, is a protein which in humans is encoded by the PARK7 gene.1j42: Crystal Structure of Human DJ-11p5f: Crystal Structure of Human DJ-11pdv: Crystal structure of human DJ-1, P 31 2 1 space group1pdw: Crystal structure of human DJ-1, P 1 21 1 space group1pe0: Crystal structure of the K130R mutant of human DJ-11ps4: crystal structure of DJ-11q2u: Crystal structure of DJ-1/RS and implication on familial Parkinson's disease1soa: Human DJ-1 with sulfinic acid1ucf: The Crystal Structure of DJ-1, a Protein Related to Male Fertility and Parkinson's Disease2or3: Pre-oxidation Complex of Human DJ-1 Protein deglycase DJ-1, also known as Parkinson disease protein 7, is a protein which in humans is encoded by the PARK7 gene. The gene PARK7, also known as DJ-1, encodes a protein of the peptidase C56 family. The human gene PARK7 has 8 Exons and locates at chromosome band 1p36.23. The human protein deglycase DJ-1 is 20 kDa in size and composed of 189 amino acids with seven β-strands and nine α-helices in total and is present as a dimer. It belongs to the peptidase C56 family of proteins. The protein structures of human protein DJ-1, Escherichia coli chaperone Hsp31, YhbO and YajL and an Archaea protease are evolutionarily conserved. Under an oxidative condition, protein deglycase DJ-1 inhibits the aggregation of α-synuclein via its chaperone activity, thus functions as a redox-sensitive chaperone and as a sensor for oxidative stress. Accordingly, DJ-1 apparently protects neurons against oxidative stress and cell death. In parallel, Protein DJ-1 acts as a positive regulator of androgen receptor-dependent transcription. Pyrroloquinoline quinone (PQQ) has been shown to reduce the self-oxidation of the DJ-1 protein, an early step in the onset of some forms of Parkinson's disease. Functional DJ-1 protein has been shown to bind metals and protect against metal-induced cytotoxicity from copper and mercury. Defects in this gene are the cause of autosomal recessive early-onset Parkinson's disease 7. PARK7 has been shown to interact with: