TMC8

147138217356ENSG00000167895ENSMUSG00000050106Q8IU68Q7TN58NM_152468NM_001195088NM_001195089NM_001195090NM_181856NP_689681NP_001182017NP_001182018NP_001182019NP_862904Transmembrane channel-like 8 is a protein which in humans is encoded by the TMC8 gene. Transmembrane channel-like 8 is a protein which in humans is encoded by the TMC8 gene. The protein encoded by this gene is an integral membrane protein that localize to the endoplasmic reticulum and is predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 8 predicted transmembrane domains and 3 leucine zipper motifs. Mutations in the TMC8 gene are associated with epidermodysplasia verruciformis (EV), an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. This article incorporates text from the United States National Library of Medicine, which is in the public domain.