IRF4

2DLL366216364ENSG00000137265ENSMUSG00000021356Q15306Q64287NM_001195286NM_002460NM_013674NM_001347508NP_001182215NP_002451NP_001334437NP_038702Interferon regulatory factor 4 also known as MUM1 is a protein that in humans is encoded by the IRF4 gene, located at 6p25-p23.2dll: Solution structure of the IRF domain of human interferon regulator factors 4 Interferon regulatory factor 4 also known as MUM1 is a protein that in humans is encoded by the IRF4 gene, located at 6p25-p23. The MUM1 symbol is polysemous; although it is an older synonym for IRF4 (HGNC:6119), it is also the current HGNC official symbol for melanoma associated antigen (mutated) 1 (HGNC:29641; located at 19p13.3). In melanocytic cells the IRF4 gene may be regulated by MITF. IRF4 is a transcription factor that has been implicated in acute leukemia. This gene is strongly associated with pigmentation: sensitivity of skin to sun exposure, freckles, blue eyes, and brown hair color. A variant has been implicated in greying of hair. IRF4 has been shown to interact with: This article incorporates text from the United States National Library of Medicine, which is in the public domain.