ARHGAP8

2377973167ENSG00000241484ENSMUSG00000078954P85298Q9CXP4NM_181335NM_001017526NM_001198726NM_001164627NM_001164628NM_001205334NM_028455NP_001017526NP_001185655NP_851852NP_001158099NP_001158100NP_001192263NP_082731Rho GTPase-activating protein 8 is a protein that in humans is encoded by the ARHGAP8 gene. Rho GTPase-activating protein 8 is a protein that in humans is encoded by the ARHGAP8 gene. This gene encodes a member of the RHOGAP family. GAP (GTPase-activating) family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. GAP proteins alternate between an active (GTP-bound) and inactive (GDP-bound) state based on the GTP:GDP ratio in the cell. Rare read-through transcripts, containing exons from the PRR5 gene which is located immediately upstream, led to the original description of this gene as encoding a RHOGAP protein containing the proline-rich domains characteristic of PRR5 proteins. Alternatively spliced variants encoding different isoforms have been described.