Polyoxins are a group of nucleoside antibiotics composed of heterocyclic moieties containing nitrogen. An example is Polyoxin B.Polyoxins work by inhibiting the biosynthesis of chitin. Polyoxins are a group of nucleoside antibiotics composed of heterocyclic moieties containing nitrogen. An example is Polyoxin B.Polyoxins work by inhibiting the biosynthesis of chitin.